James Ransone — an actor best known for his role in the hit show “The Wire” — has died … and the medical examiner is pointing to suicide as the cause.

TMZ has independently confirmed the star passed away Friday … and the M.E.’s website lists the manner of death as suicide by hanging. We’ve also learned the Los Angeles Police Department responded to a call to a residence, where officers completed a death investigation report and no foul play was suspected.

Ransone started appearing in small roles in the early 2000s … grabbing parts in the TV shows “Ed” and “Third Watch” … before landing his breakout part in “The Wire.”

Ransone’s other credits include … “CSI: Crime Scene Investigation,” “Hawaii Five-0,” “Burn Notice,” “Tangerine,” and the Stephen King film, “It: Chapter Two.”

He had a part in “The Black Phone” and “The Black Phone 2” … the latter of which was released earlier this year.

Ransone was 46.

RIP

Aside from being a pop star, Dua Lipa has clearly mastered the art of vacationing — and we caught her doing exactly that in Mexico on Saturday … hitting the beach in a teeny bikini and turning up the heat with some serious PDA with her fiancé, Callum Turner.

Check out the pics … the “Physical” hitmaker showed off her toned physique in a cheetah print thong bikini … allowing nearly every inch of her skin access to some sun action. At one point, she shimmied her way out of her bikini top to allow Callum to give her a full-body sunscreen rubdown.

The pair could barely keep their hands off each other, and at one point … had their arms wrapped around each other as they took a romantic stroll along the beach.

Dua fully earned her R&R, as she wrapped her “Radical Optimism” tour at the beginning of the month. She spent just over a year on the road bringing her music to fans around the world … but she made sure she got some days off, too.

Nearly a dozen gunmen reportedly opened fire outside a bar in South Africa, killing 9 people and injuring 10.

The mass shooting was the second in South Africa in the last 3 weeks, with the latest incident occurring early Sunday morning in Bekkersdal, a township 28 miles west of Johannesburg, according to CBS.

When the smoke cleared, nine people were reportedly dead and 10 more injured. The conditions of the survivors are not known.

Police told CBS that some of the victims were randomly shot, and a ride-sharing driver — who had just dropped off a passenger — was among the dead.

The Associated Press, citing a police official, said the gunmen were armed with mostly 9 millimeter semi-automatics and at least one AK-47. A manhunt is underway to capture the killers.