Perhaps the most famous grandma on TikTok, Epic Gamer Grandma, has died.

Her passing was confirmed by her grandson Culsan in an Instagram post Tuesday. In it, Culsan listed her date of death as December 21.

According to Culsan, his grandmother passed away “holding the hand of her daughter, Pauline.”

The TikTok star, whose real name was Agnes, garnered more than 2 million followers on the platform.

Culsan posted several health updates about his grandmother in the weeks leading up to her passing.

The first update came in October after Agnes had been hospitalized for COPD. At the time, Culsan asked fans for their “prayers or thoughts,” hoping to be able to give a positive update in the future.

The following month, Culsan returned with an “upsetting update” that it was looking “increasingly more likely” Agnes would not be able to come home.

She was 78.

The body of a 9-year-old California girl has been found two months after she vanished during an impromptu mother-daughter trip … leading to the arrest of her mother.

Authorities say Melodee Buzzard’s body was found in Utah earlier this month, and her mother, Ashlee Buzzard, was taken into custody Tuesday in connection with the child’s death.

Officials confirmed Melodee was found in an area she had traveled to with her mom back in October … and investigators believe she was killed there before her disappearance made headlines, KABC-TV reports.

Family members paint a troubling picture, calling Ashlee “extremely mentally unstable” — and authorities say she refused to cooperate with investigators as the case unfolded. She hasn’t yet been charged.

Greg Biffle and his wife sent their holiday card in the mail before they died in a fatal plane crash … and the season’s greeting is just now showing up in mailboxes of relatives and friends.

One of Biffle’s friends, a restaurant owner in North Carolina named Ron Herbert, says he checked his mail Sunday and found a holiday card from the Biffles.

Herbert shared the card on social media … and it shows Greg, wife Cristina, his daughter Emma, and their son Ryder in matching outfits — blue jeans and white shirts — smiling and laughing in front of flocked Christmas trees.