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The U.S. just bet $1 billion that AI supercomputers can turn most cancers from ‘death sentences’ to ‘manageable conditions’ within 8 years

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The U.S. government is making a billion-dollar bet that AI can do what decades of “moonshots” have failed to: make cancer more manageable and much more survivable.

In a newly announced partnership with Advanced Micro Devices, the Department of Energy (DOE) will build two of the world’s most advanced AI supercomputers—Lux and Discovery—to accelerate research across fusion energy, national defense, and cancer treatment, according to a Reuters report.

Energy Secretary Chris Wright told Reuters the machines could, in “the next five or eight years,” help turn “most cancers, many of which today are ultimate death sentences, into manageable conditions.”

For scientists like Trey Ideker, who leads a precision-oncology program at the Advanced Research Projects Agency for Health at the U.S. Department of Health and Human Services, the claim is both exciting and incomplete.

“Can we make a massive dent in cancer with AI and big data in the next eight years? Absolutely,” he told Fortune. “Is AI alone going to solve cancer? No.”

The real bottleneck: Data, not compute

For all their power, Lux and Discovery can’t learn without fuel. Ideker argues the field’s biggest challenge is integrating multimodal data—from genetic sequences to tissue scans to body imaging—needed to predict how a patient will respond to treatment.

He compares cancer’s data shortage to other AI domains. Large language models (LLMs) like ChatGPT have the internet; self-driving cars like Waymo have millions of logged hours on the road. Cancer, by contrast, has only as much data as hospitals are able and willing to share.

“The cancer space is more data-limited,” Ideker said. “We have to invest just as heavily in capturing and linking that data as we do in compute.”

He believes the DOE’s hardware should be connected directly to ongoing federal programs such as ARPA-H’s ADAPT initiative, which collects patient data to train models predicting drug response.

“Bringing the AI and the data together,” he said, “is what will make this work.”

Ideker’s favorite metaphor for the near-term future of AI in medicine isn’t an autonomous robot surgeon; rather, he sees AI as a new seat in the boardroom.

“When patients stop responding to first-line treatments, their cases go to these meetings,” he said. “Ten or 12 Jedis—MDs and PhDs—sit around a boardroom like an episode of House M.D. and debate what to try next.”

Sometimes it’s arbitrary, he said: Someone remembers a study from last week and argues to try the drug from the study. He imagines AI as “the quiet assistant in the corner” that has read all the literature and knows every trial result.

“It’s not going to pull the trigger on treatment,” he said. “It’ll just offer an opinion, and the physicians will have to respect that it’ll often be the only thing in the room that’s read everything.”

At UCSD’s Moores Cancer Center, Ideker’s team is already running a clinical trial built around that model. He expects oncologists to welcome the help, especially in hard cases.

“AI isn’t going to ride in on a white horse,” he said. “It’s already flowing in at a moderate pace.”

2033: A plausible future

By the early 2030s, Ideker thinks nearly every patient could receive the best existing therapy for their specific tumor, a true realization of precision medicine, where he specializes. Designing new drugs in real time for resistant cancers will take longer, though. 

For now, he’d rather see policymakers focus on wiring the new compute power into real hospital data systems.

“If there’s one thing—selfishly—that would really benefit science,” he said, “it’s connecting these AI efforts to the places generating the data they need.”

As for Wright’s line about the “beginning of the end” of cancer as a death sentence, Ideker calls it “inspiring, but it needs unpacking.” 

“I think we’ll solve the first part—matching every patient to the best existing treatment—by 2030,” Ideker said. “But what if there are no treatments that work for your tumor? That’s when we’ll need ways of designing drugs in real time for each patient. I’d bet that won’t be solved by 2030, but people should be thinking about it.”



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Hegseth likens strikes on alleged drug boats to post-9/11 war on terror

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Defense Secretary Pete Hegseth defended strikes on alleged drug cartel boats during remarks Saturday at the Ronald Reagan Presidential Library, saying President Donald Trump has the power to take military action “as he sees fit” to defend the nation.

Hegseth dismissed criticism of the strikes, which have killed more than 80 people and now face intense scrutiny over concerns that they violated international law. Saying the strikes are justified to protect Americans, Hegseth likened the fight to the war on terror following the Sept. 11, 2001 attacks.

“If you’re working for a designated terrorist organization and you bring drugs to this country in a boat, we will find you and we will sink you. Let there be no doubt about it,” Hegseth said during his keynote address at the Reagan National Defense Forum. “President Trump can and will take decisive military action as he sees fit to defend our nation’s interests. Let no country on earth doubt that for a moment.”

The most recent strike brings the death toll of the campaign to at least 87 people. Lawmakers have sought more answers about the attacks and their legal justification, and whether U.S. forces were ordered to launch a follow-up strike following a September attack even after the Pentagon knew of survivors.

Though Hegseth compared the alleged drug smugglers to Al-Qaida terrorists, experts have noted significant differences between the two foes and the efforts to combat them.

Hegseth’s remarks came after the Trump administration released its new national security strategy, one that paints European allies as weak and aims to reassert America’s dominance in the Western Hemisphere.

During the speech, Hegseth also discussed the need to check China’s rise through strength instead of conflict. He repeated Trump’s vow to resume nuclear testing on an equal basis as China and Russia — a goal that has alarmed many nuclear arms experts. China and Russia haven’t conducted explosive tests in decades, though the Kremlin said it would follow the U.S. if Trump restarted tests.

The speech was delivered at the Reagan National Defense Forum at the Ronald Reagan Presidential Foundation and Institute in California, an event which brings together top national security experts from around the country. Hegseth used the visit to argue that Trump is Reagan’s “true and rightful heir” when it comes to muscular foreign policy.

By contrast, Hegseth criticized Republican leaders in the years since Reagan for supporting wars in the Middle East and democracy-building efforts that didn’t work. He also blasted those who have argued that climate change poses serious challenges to military readiness.

“The war department will not be distracted by democracy building, interventionism, undefined wars, regime change, climate change, woke moralizing and feckless nation building,” he said.



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US debt crisis: Most likely fix is severe austerity triggered by a fiscal calamity

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One way or another, U.S. debt will stop expanding unsustainably, but the most likely outcome is also among the most painful, according to Jeffrey Frankel, a Harvard professor and former member of President Bill Clinton’s Council of Economic Advisers.

Publicly held debt is already at 99% of GDP and is on track to hit 107% by 2029, breaking the record set after the end of World War II. Debt service alone is more than $11 billion a week, or 15% of federal spending in the current fiscal year.

In a Project Syndicate op-ed last week, Frankel went down the list of possible debt solutions: faster economic growth, lower interest rates, default, inflation, financial repression, and fiscal austerity. 

While faster growth is the most appealing option, it’s not coming to the rescue due to the shrinking labor force, he said. AI will boost productivity, but not as much as would be needed to rein in U.S. debt.

Frankel also said the previous era of low rates was a historic anomaly that’s not coming back, and default isn’t plausible given already-growing doubts about Treasury bonds as a safe asset, especially after President Donald Trump’s “Liberation Day” tariff shocker.

Relying on inflation to shrink the real value of U.S. debt would be just as bad as a default, and financial repression would require the federal government to essentially force banks to buy bonds with artificially low yields, he explained.

“There is one possibility left: severe fiscal austerity,” Frankel added.

How severe? A sustainable U.S. debt trajectory would entail elimination of nearly all defense spending or almost all non-defense discretionary outlays, he estimated.

For the foreseeable future, Democrats are unlikely to slash top programs, while Republicans are likely to use any fiscal breathing room to push for more tax cuts, Frankel said.

“Eventually, in the unforeseeable future, austerity may be the most likely of the six possible outcomes,” he warned. “Unfortunately, it will probably come only after a severe fiscal crisis. The longer it takes for that reckoning to arrive, the more radical the adjustment will need to be.”

The austerity forecast echoes an earlier note from Oxford Economics, which said the expected insolvency of the Social Security and Medicare trust funds by 2034 will serve as a catalyst for fiscal reform.

In Oxford’s view, lawmakers will seek to prevent a fiscal crisis in the form of a precipitous drop in demand for Treasury bonds, sending rates soaring.

But that’s only after lawmakers try to take the more politically expedient path by allowing Social Security and Medicare to tap general revenue that funds other parts of the federal government.

“However, unfavorable fiscal news of this sort could trigger a negative reaction in the US bond market, which would view this as a capitulation on one of the last major political openings for reforms,” Bernard Yaros, lead U.S. economist at Oxford Economics, wrote. “A sharp upward repricing of the term premium for longer-dated bonds could force Congress back into a reform mindset.”



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The $124 trillion Great Wealth Transfer is intensifying as inheritance jumps to a new record

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Nearly $300 billion was inherited this year as the Great Wealth Transfer picks up speed, showering family members with immense windfalls.

According to the latest UBS Billionaire Ambitions Report, 91 heirs inherited a record-high $297.8 billion in 2025, up 36% from a year ago despite fewer inheritors.

“These heirs are proof of a multi-year wealth transfer that’s intensifying,” Benjamin Cavalli, head of Strategic Clients & Global Connectivity at UBS Global Wealth Management, said in the report.

Western Europe led the way with 48 individuals inheriting $149.5 billion. That includes 15 members of two “German pharmaceutical families,” with the youngest just 19 years old and the oldest at 94.

Meanwhile, 18 heirs in North America got $86.5 billion, and 11 in South East Asia received $24.7 billion, UBS said.

This year’s wealth transfer lifted the number of multi-generational billionaires to 860, who have total assets of $4.7 trillion, up from 805 with $4.2 trillion in 2024.

Wealth management firm Cerulli Associates estimated last year that $124 trillion worldwide will be handed over through 2048, dubbing it the Great Wealth Transfer. More than half of that amount will come from high-net-worth and ultra-high-net-worth people.

Among billionaires, UBS expects they will likely transfer about $6.9 trillion by 2040, with at least $5.9 trillion of that being passed to children, either directly or indirectly.

While the Great Wealth Transfer appears to be accelerating, it may not turn into a sudden flood. Tim Gerend, CEO of financial planning giant Northwestern Mutual, told Fortune’s Amanda Gerut recently that it will unfold more gradually and with greater complexity

“I think the wealth transfer isn’t going to be just a big bang,” he said. “It’s not like, we just passed peak age 65 and now all the money is going to move.”

Of course, millennials and Gen Zers with rich relatives aren’t the only ones who sat to reap billions. More entrepreneurs also joined the ranks of the super rich.

In 2025, 196 self-made billionaires were newly minted with total wealth of $386.5 billion. That trails only the record year of 2021 and is up from last year, which saw 161 self-made individuals with assets of $305.6 billion.

But despite the hype over the AI boom and startups with astronomical valuations, some of the new U.S. billionaires come from a range of industries.

UBS highlighted Ben Lamm, cofounder of genetics and bioscience company Colossal; Michael Dorrell, cofounder and CEO of infrastructure investment firm Stonepeak; as well as Bob Pender and Mike Sabel, cofounders of LNG exporter Venture Global.

“A fresh generation of billionaires is steadily emerging,” UBS said. “In a highly uncertain time for geopolitics and economics, entrepreneurs are innovating at scale across a range of sectors and markets.”



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