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The dangerous side of popular sleep and anxiety drugs like Xanax and Lorazepam

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If you’ve been HBO’s new season of White Lotus, then you’ve seen Parker Posey’s character Victoria Ratliff popping a steady stream of Lorazepam while on a family vacation at a Thailand wellness resort, at one point comically declaring, “Someone stole my Lorazepam. I’m going to have to drink myself to sleep.” 

The drug, also known under the brand name Ativan, is part of a class called benzodiazepines, which also includes Xanax and Klonopin. Only available through prescription, they are used to help relieve anxiety and muscle spasms, and reduce seizures, according to the DEA. However, as seen in the show, they can lead to dependence and overuse. 

“We definitely see that a lot in real life as well,” Dr. Ian Neel, a geriatrician at UC San Diego Health, tells the New York Times about the class of drugs.

Of the over 30 million adults who reported using benzodiazepines in the last year, over 5 million misused them (described as “any way a doctor did not direct”), per 2019 data from the National Survey on Drug Use and Health

While some people may have taken a one-time Xanax to calm flight anxiety, for example, long-term use is what poses the most danger as it can lead to dependence. People can become dependent even when taking the prescribed amount, Dr. Ludmila De Faria, chair of the American Psychiatric Association’s council on women’s mental health, told the New York Times. 

Particularly important is the appeal of “benzos” to older adults: Those ages 50 to 64 are the biggest consumers of this class of drugs, according to the 2019 study, and need to use extra caution due to the drugs’ potential effects on slowing cognition.

The class of drugs slows down the nervous system and often takes an immediate effect. And while they are generally safe when taken as prescribed for a limited time, side effects include drowsiness, memory problems, and slurred speech. Overuse can cause worsened effects, including dependence, cognitive impairment, coma, and potential death, although rare. 

Neel cautioned that older adults may metabolize drugs differently, and should be aware of the potential for negative interactions with other medications and drugs they might be taking. Combining benzodiazepines with other depressants like alcohol, for example, can exacerbate feelings of sedation, as seen on White Lotus, as Posey’s character usually pops Lorazepam with a glass of wine. 

When regular users of benzodiazepines—often called benzos—try to wean off the drugs, it’s common to experience withdrawal symptoms, like sweating, headaches, and heart palpitations according to the American Addiction Centers

“Each benzodiazepine medication has a specific half-life that influences the length of time it takes for the drug to leave the bloodstream,” according to the Center. “If an individual is dependent on a benzo, once the drug is purged from the body, withdrawal may begin.” 

It’s important to talk to a medical doctor and a mental health professional if you think you’re experiencing any withdrawal symptoms or negative side effects from benzodiazepines because there are other ways to treat anxiety and sleep orders. “The first-line treatment [for anxiety] is typically antidepressants like SSRIs [antidepressants], plus psychotherapy,” Dr. David Merrill, a geriatric psychiatrist at Providence Saint John’s Health Center in Santa Monica, Calif. told Healthline.

For more on sleep, mental health, and more:

This story was originally featured on Fortune.com



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Americans see growing risk they’ll get turned down for loans

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A growing share of US consumers say they’re not seeking loans because they expect to be refused amid tight credit conditions, according to data from the Federal Reserve Bank of New York. 

The share of discouraged borrowers, defined as respondents who said they needed credit but didn’t apply because they didn’t expect to get approved, climbed to 8.5% in the New York Fed’s latest Survey of Consumer Expectations. That’s the highest level since the study began in 2013.

The perceived likelihood of being rejected increased across different forms of credit, from cards to secured loans to buy homes and cars. Roughly one-third of auto loan applicants expected to get turned down, the highest share since the start of the series, while nearly half of all respondents in the February survey said it’ll be harder to get credit in a year’s time.

The data adds to a picture of increasingly fragile household finances for many Americans, as a cooling job market slows wage gains while high borrowing costs are making bills harder to pay. Delinquency rates remain low by pre-pandemic standards but they’ve been edging higher in most categories, and lenders are turning cautious.  

More than four in 10 US homeowners who sought to refinance their mortgages had their applications rejected, according to the February survey, quadruple the share in October 2023. 

With mortgage lending rates still much higher than a couple of years ago, many people seeking a refi are likely trying to tap equity accumulated during the recent housing boom in order to meet other debt costs or expenses, rather than to reduce their monthly payments. Inability to do so could put some under pressure to sell their homes. 

Meanwhile, the share of consumers in the New York Fed survey who said they could come up with $2,000 in the event of an unexpected need declined to 63%, a new series low.

This story was originally featured on Fortune.com



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Gavin Newsom is welcoming prominent conservatives on his new podcast, but critics say it’s risky to align himself ‘in a slightly unpredictable middle’

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California Gov. Gavin Newsom holds a fireside chat with Stephen Cheung, the President and Chief Executive Officer of the Los Angeles County Economic Development Corporation (LAEDC) and its subsidiary, the World Trade Center Los Angeles (WTCLA) at the 2025 Economic Forecast and Industry Outlook convening on Wednesday, Feb. 26, 2025, at the East LA College in Los Angeles.

Damian Dovarganes—AP Photo



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Multimillionaire musician Will.i.am invested early in Tesla, Twitter, and OpenAI—now he’s betting on Gen Z MIT and Stanford grads for his next investment

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  • Will.i.am has an estimated net worth of $50 million, thanks to hit singles and solid investments in the likes of Anthropic and Pinterest. In a conversation with Fortune, he reveals where he’s investing next.

Black Eyed Peas front man Will.i.am has built a fortune off chart-topping hits like “Scream & Shout” and “Where Is the Love?” As of 2025, he’s reportedly worth around $50 million, according to Celebrity Net Worth—but it’s not just music that’s made him millions. 

Beyond his success in the studio, he was an early investor in Tesla, Pinterest, and OpenAI, proving his business instincts are just as sharp as his songwriting. Now the rapper, producer, and The Voice UK judge has revealed what he’s looking for from his next investment.

“I did some pretty cool investments in the past,” Will.i.am (real name: William James Adams Jr.) told Fortune, while listing Pinterest, Dropbox, Open AI, and Anthropic as some of his smartest bets.

“I invested in Tesla in 2006, before Elon [Musk] took over the company, and he’s done great, taking it to where it is. Hopefully, he can figure out a way to get it back to its glory,” he added. “I invested in Twitter early on. When Jack [Dorsey] left, I sold it. Made good there.”

So, what’s Will.i.am looking for in his next investment? “I’m hunting for what they call large concept models,” the 50-year-old Grammy Award–winning artist revealed. 

“Right now, we’re in large language models, but they’re not concepts. It’s just language—they’re just regurgitating our imagination and our concepts,” he explained. 

“Around the corner, someone’s going to build large concept models. So you want to hunt for that. You want to hunt for the people that are out there doing that. They’re students right now, they’re at MIT, they’re at Stanford. They’re young kids, and they’re native to this. So you want to hunt for that. That’s the only thing I’m focused on.”

Will.i.am has a long history as a futurist and tech entrepreneur. In 2011, Intel named him its “director of creative innovation.” His startup, i.am+, raised $117 million in 2017. Now, Will.i.am has set his sights on AI. He most recently founded FYI—an AI-driven productivity and communication platform for creatives—where he serves as CEO. 

Will.i.am was speaking to Fortune in Rome for the rollout of Raidio.FYI radios in Mercedes-Benz cars.

Will.i.am’s biggest investment mistake

For all his successes, there’s one missed opportunity that still haunts Will.i.am: declining to invest in Airbnb when he had the chance. 

Its founder Brian Chesky approached the rapper in the company’s early days with an opportunity to invest up to $200,000 in a fundraising round, but Will.i.am was skeptical.

“When you travel and you have success, you get used to the best hotels, the best service, right? So sometimes, when you’re used to the best, and you’re used to being pampered by the best, that could cripple you because when new experiences come, like Airbnb, you’re gonna base it off of the best,” he explained.

“You’re gonna say, hey, so you guys have concierge, and he’s gonna say, no. That ain’t gonna work. So you guys have room service? No. That ain’t gonna work. So I was tunnel vision and pampered by luxury.”

Airbnb went on to have one of the most successful IPOs in history in December 2020. Had he taken Chesky up on the offer, Will.i.am’s $200,000 stake could be worth millions of dollars today.

This story was originally featured on Fortune.com



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